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Modeling an alternative treatment intensification regimen, with oral semaglutide and liraglutide continued alongside basal insulin before intensification to basal-bolus insulin, led to improved life expectancy (0.03 years) and quality-adjusted life expectancy (0.22 QALYs) outcomes with oral semaglutide

384,385 Additionally, GWAS has identified several novel genetic loci associated with DPN, underscoring the complex genetic architecture underlying this condition