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Intrauterine devices (IUDs) that release progestin, such as the levonorgestrel-releasing IUS, are used primarily to control heavy menstrual bleeding associated with fibroids

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However, Lip-1 administration abolished the antitumor effects of erastin (Zhang et al., 2019)

Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload