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For instance, elevated 4-HNE in synovial fluid has been reported in multiple studies, but significant variations in detection methods and patient stratification such as disease stage and inflammation degree between studies mean the strength of evidence for 4-HNE as a driver of OA inflammation amplification still requires cautious interpretation

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The current guideline recommendations state that for grade 2 and 3 irAEs, when symptoms and/or laboratory values return to grade 1 or less, cautious rechallenge with ICIs may be offered