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What changes after 40 is the physiological environment those medications interact with

23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

J Hepatol 2006;44(1 Suppl):S132-9

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