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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)
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102,319,320,321 A single-center double-blind, randomized, parallel placebo-controlled study found that uric acid reduction slowed the decline of glomerular filtration rate in patients with stage 3 and 4 CKD
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