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Their effects likely arise from a convergence of pathways: indirectly, through systemic improvements in glycemic control and metabolism, and directly, via the activation of intraocular GLP-1Rs on cells like retinal Mller and ganglion cells, which triggers local anti-inflammatory, anti-oxidant, and anti-apoptotic responses

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If you or a loved one has experienced unexplained GI problems, kidney issues or other serious symptoms after starting a GLP-1 drug, look into your rights

This has led to hypotheses about indirect roles via sleep regulation and immune activity, though the research is still at an exploratory stage