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Molecular mechanisms Two major pathophysiological causes of many diseases are endothelial dysfunction and oxidative stress

The body needs cysteine to produce and replenish glutathione, a powerful antioxidant

Some studies suggest GLP-1s may even have neutral or protective effects on bone health

For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting