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It inhibits kidney fibrosis and damage induced by LPS, aristolochic acid I, Cisplatin, adenine, adriamycin, Ang II, excessive fructose, unilateral ureteral obstruction, and 5/6 nephrectomy through its antioxidant and anti-inflammatory properties, as well as by modulating mitochondrial pathways

Ethics statement Use of human erythrocytes was approved by the La Trobe University Research Ethics Committee (ethics number HEC17013) and an Australian Red Cross Blood Service Agreement (Deed 19-05VIC76 01)

2,3 Phase 3 Evidence: REDEFINE Trial Program The NDA is supported primarily by results from the phase 3 REDEFINE clinical trial program, including REDEFINE 1 and REDEFINE 2