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Research reveals that platinum-resistant HGSOC cells often exhibit suppression of Homologous Recombination (HR) repair pathways, while alternative repair mechanisms, such as Non-Homologous End Joining (NHEJ), are activated ( Single-cell RNA sequencing has revealed specific drug-resistant cell subpopulations in HGSOC that promote their growth and drug resistance through interactions with fibroblasts and endothelial cells in the tumor microenvironment ( 3.3 Apoptosis and autophagy In the apoptotic pathways of tumor cells and HGSOC cells, key proteins such as the Bcl-2 family, p53, and caspases play crucial roles ( p53, as a tumor suppressor, promotes apoptosis by inducing the expression of apoptosis-related genes, particularly in cases of DNA damage ( Autophagy plays a dual role in the drug resistance of tumor cells and HGSOC
Relaix, F
In the STEP 1 trial published in the New England Journal of Medicine, participants taking semaglutide lost an average of about 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group, and 86.4% of participants achieved at least 5% weight loss
Microglial activation: Key players in sepsis-associated encephalopathy
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