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High-fat-fed ApoE / mice exhibit larger atherosclerotic plaques, severe ferroptosis, increased NOX production, and reduced GSH and xCT expression in the thoracic aorta compared to wild-type mice (Li et al., 2021)

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The reduced model (Figure 2A) is crucial in that it contains all of the components that are relevant to the dynamics of the methionine cycle even when excised from the full network