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Exendin-4 (a peptide that shares 53% amino acid sequence with native GLP-1), however, was found to be effective in rat models for preventing 6-OHDA-induced DA-ergic neuron loss and increasing the number of neural stem cells in the subventricular zone ( 3.2.2.2 Clinical studies At the clinical level, RCTs have been carried out to evaluate the effects of some GLP-MA in PD patients (Table 2) (Hlscher, 2024)

Human data is still very limited, including small pilot work such as the knee pain survey of 16 patients, plus a few other early studies and reviews calling out the lack of large, rigorous trials

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