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The primary safety concerns include immunogenicity (development of antidrug antibodies), gastrointestinal reactions, and contamination risks in unregulated products

Circadian-regulated molecules such as TNF-, leptin, -amyloid, delta sleep-inducing peptide (DSIP), and prostaglandin D 2 (PGD 2 ) are expressed in the central nervous system and may influence stroke pathogenesis by altering BBB circadian dynamics (4650)

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