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These metabolic shifts may contribute to improved endurance capacity and delayed fatigue onset during prolonged physical activity

and 27% of patients were lost or unsuitable for evaluation , meaning the headline denominator is 49, not 67

Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants

Ridet JL, Bensadoun JC, Deglon N, Aebischer P, Zurn AD