semaglutide recombinant synthesis WO2022064517A1 - A process for the preparation of and semapeptide Method for preparing semaglutide by

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The preparation method comprises: obtaining a compound having a structure represented as the formula I by taking a resin, activating the resin, and coupling L-glycine, L-arginine, L-glycine, L-arginine, L-valine, L- leucine, L-tryptophan, L-alanine, L-isoleucine, L-phenylalanine, and L-glutamic acid to the activated resin step by step so as to obtain a first peptide resin

Physical properties: It is slightly soluble in water and soluble in some organic solvents such as methanol and acetonitrile

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