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The idea that systems (including the planet) may be close to a point of change where a small amount of force could cause a major transformation, is intuitive and powerful, especially in light of the increasing frequency of extreme weather events, and the palpable advent of the age of permanent crisis (Chakravarty, 2024)

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c-Met is also involved in the resistance mechanism of sorafenib, which can be solved by the combination of c-Met inhibitor and sorafenib

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