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Greater cerebrovascular resistance is indicative of constricted downstream vessels (higher vascular tone) in the cerebral circulation, restricting perfusion into cerebral tissues (Yew and Nation, 2017)

If side effects remain problematic, specific supplements may help manage individual symptoms

Folinic acid can enter the brain and normalize the level of folate coenzymes and has been shown to normalize folate concentrations and improve various social interactions in CFD, including mood, behavior, and verbal communication in children with ASD (190, 195, 196)

The mechanism of placental NAD(P)H activation is still unclear, but the above findings may assist in elucidating the role of OS in the pathogenesis of placental dysfunction in reproductive diseases such as preeclampsia