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4 Epigenetics Epigenetic research involves heritable changes that affect gene expression without altering the DNA sequence, including DNA methylation, histone modifications, microRNA(miRNAs) and Long Non-Coding RNAs (lncRNAs) regulation

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This multistep procedure performs the preliminary hydrogen atoms addition employing the pdb2pqr 46 and PROPKA3 47 software combination through the systemPrepare HTMD implementation 48 , considering a simulated pH of 7.4

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