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Cutaneous adverse reactions to antibiotics extra information Synonyms: Antibiotic-induced rashes Categories: Reactions, Infections, Treatments Reactions Infections Treatments Author: Dr Aarthy Uthayakumar, Core Medical Trainee, University College Hospital London, London, United Kingdom

36 In addition, certain metals may affect gene expression and alter gene function

This regulatory effect is partly mediated via the AMPK/sirtuin-1 (SIRT1) axis, as knockdown of SIRT1 abrogated the lipid-lowering and autophagy-inducing effects of GLP-1RAs, highlighting a crucial role of this pathway in regulating lipid metabolism by facilitating degradation of lipid droplets, thus preventing excessive lipid accumulation (12)

doi: 10.1016/s0014-2999(99)00486-0