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The hair clinical trials used topical formulations, and scalp delivery allows targeted concentration at the follicle level

Insider's takeaway The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

In other aspects, the invention provides methods of preventing dementia in a patient with Parkinson's disease and/or of improving or restoring cognitive function in a patient with Parkinson's disease

If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs