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Addressing clinical limitations of glutaminase inhibitors: novel strategies for osimertinib-resistant lung cancer by exploiting glutamine metabolic dependency

Glutathione's role as the cell's master antioxidant and as a cofactor in hepatic detoxification is well established at the biochemical level it neutralizes free radicals and participates directly in the liver's clearance of toxins and heavy metals

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When Phase I runs faster than Phase II (from enzyme induction, genetic polymorphisms, or cofactor depletion), reactive intermediates accumulate and cause oxidative damage to DNA, lipids, and proteins