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Examination of glutathione depletion and mitochondrial ROS formation as toxicity mechanisms in drug-treated liver models Recently, it has been shown in mice that mitochondrial ROS formation plays a major role in TVX-mediated hepatotoxicity 37

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Crucially, this decrease was primarily attributable to a reduction in candy consumption, while chow intake increased compared to vehicle-treated controls with access to both food types (Raun et al., 2007)