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TBHP, tert-butyl hydroperoxide (an oxidative stress inducer)

For most patients, taking both is safe with correct timing

Moreover, another study of DOX-induced nephrotoxicity in SD rats proved that L-theanine could protect the kidney by reducing the levels of oxidized glutathione (GSSG), gamma-glutamyltransferase 1 (GGT1), NF-B p65, and the percentage of apoptosis indexes in the tissue and plasma, and increasing the levels of GSH and the activities of GPx, glutathione reductase (GR), and glutathione S-transferase (GST) (86)

Mitochondrial dysfunction resulting from accumulation of trans-activation response element DNA binding protein 43 (TDP-43) increases the production of ROS, causing oxidative stress and establishing a vicious cycle that contributes to disease progression