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View Study [4]"Development of Cagrilintide, a Long-Acting Amylin Analogue" Kruse T et al., 2021 Finding: Describes the medicinal chemistry development of cagrilintide, explaining how lipidation extended the half-life from minutes (pramlintide) to approximately one week while maintaining receptor activity

Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)

This anti-inflammatory activity occurs without apparent immunosuppression, suggesting selective modulation of inflammatory pathways rather than global immune suppression

To address this knowledge gap, we conducted a real-world cohort study using the TriNetX database to evaluate the comparative effectiveness of tirzepatide versus GLP-1 RAs in reducing the 1-year incidence of VTE in patients with obesity