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L-carnitine plays a key role in regulating acyl-CoA and acetyl-CoA and in maintaining free CoA levels within mitochondria, which is essential for maintaining metabolic flexibility (Figure 1) (18)

Angley M, Zhang Y, Koutrakis P, Kahe K

The upregulation of type A monoamine oxidase (MAOA) and the downregulation of serotonin (5-hydroxytryptamine, 5-HT) and NE levels in the brain are considered to be the primary etiological factors underlying depression

341 Schwann cell injury In DPN, hyperglycemia and oxidative stress lead to Schwann cell dysfunction and apoptosis, resulting in demyelination and impaired nerve conduction