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The FPKM can be obtained from the authors on request

It often builds gradually, which is why knowing the markers that separate tough-but-manageable nausea from a medical emergency matters: Unable to keep any liquid down for 24+ hours Visible weight loss Extreme weakness or fainting Dark urine that persists despite attempts to drink When nausea is present but manageable, the goal shifts from hitting a perfect daily number to simply keeping fluids moving through your system