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This multimodal approach connected known T2D GWAS variants through an RFX6 -regulated gene network and identified novel non-coding RFX6 variants causally associated with diabetes development, placing RFX6 at the center of a complex genetic network that increases the risk of T2D

Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, Levine DA, McNeish IA, Menon U, Mills GB, Nephew KP, Oza AM, Sood AK, Stronach EA, Walczak H, Bowtell DD, Balkwill FR (2011) Rethinking ovarian cancer: recommendations for improving outcomes

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So, while 503A is all about the individual, 503B is geared towards supplying healthcare facilities more broadly