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This therapeutic effect was mechanistically linked to reductions in pro-inflammatory cytokines (TNF-, IL-1), enhancement of antioxidant defenses (e.g., increased superoxide dismutase activity), suppression of apoptosis via caspase-3 inhibition, and modulation of NF-B pathwayscollectively yielding neuroprotection and symptomatic relief ( Curcumin shows therapeutic potential for managing peripheral neuropathic pain through multiple mechanisms (Zhang et al., 2020b)

Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995)

Thirty-four percent of covered workers are in plans with a general annual deductible of $2,000 or more for single coverage, similar to the percentages last year (32%) but higher than the amount five years ago (26%) [Figure 7.14]