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The nature of this compensatory mechanism in GLP-1 receptor KO mice at high oral glucose load is not known but deserves further studies candidates may be the higher baseline glucose levels or compensatory increase in other gut hormones which may mask the consequence of GLP-1 receptor gene deletion

By the second month, many of the initial gastrointestinal side effects often become less frequent or less severe as your body adjusts to the medication and potentially to a higher dose (e.g., 7.5 mg weekly)

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Incretins are a group of gastrointestinal hormones that stimulate lower blood glucose levels by increasing the amount of insulin released from pancreatic beta cells