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It's reconstituted with bacteriostatic water before use

Additionally, it may not be recommended for individuals with a history of certain medical conditions, such as thyroid cancer or pancreatitis

Compared with women without sickle cell disease, the review reports markedly higher risks: 6.0-times higher maternal mortality (95% CI 1.9 to 18.4) 2.4-times higher pre-eclampsia (95% CI 1.8 to 3.4) 3.9-times higher stillbirth (95% CI 2.6 to 6.0) 2.2-times higher preterm delivery (95% CI 1.5 to 3.3) 3.7-times higher small-for-gestational-age infants (95% CI 2.3 to 6.0) Much of this seems to come down to impaired placental blood flow and features of placental insufficiency

doi: 10.1038/nrendo.2011.128 34 BartalenaLKahalyGJBaldeschiLDayanCMEcksteinAMarcocciCet al