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10.1016/j.brainresbull.2022.11.005 Brain Res

In platinum-resistant disease, lactate accumulation is accompanied by GCN5-dependent H3K9la and RAD51 K73 lactylation, which upregulate RAD51/BRCA2, strengthen homologous recombination repair, and reduce cisplatin sensitivity

Safety Profile: Preclinical studies suggest high specificity, but the potential for overkill in tissues where transient senescence is required for wound healing or tumor suppression remains a point of scholarly debate (Rabinovitch, 2023)

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