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Even human therapeutic monoclonals antibodies (such as Lanadelumab and garadacimab, both of the two authorized therapeutic monoclonal antibody with hereditary angioedema indication) are potentially immunogenic, since they contain unique amino-acid sequences in their antigen-binding hypervariable region (CDR) in high dose

Johansson, L., G

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The disproportionation of O 2 - (either naturally or through the action of SOD) results in the formation of H 2 O 2 , which can be fully reduced to H 2 O or partially to OH, known to be among the most potent oxidants in nature (Turrens, 2003)