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Pediatr Res 2003 53:3

90 In the UPS, the E3 ligase is considered an important component of the ubiquitin binding system and plays a role in substrate-specific recognition

Natural history studies that have tracked the progression of relapsing-onset MS in untreated MS populations have reported that men are at higher risk for development (8) and have a shorter time to conversion to SP-MS (7, 24, 25)

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