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Glutathione deficiency leads to: Increased oxidative stress Accumulation of toxins and heavy metals Inability to repair DNA Cell mutation Reduced supply of oxygen and nutrients to the cells Eventual cell death People who consider themselves to be in good health may not necessarily be glutathione deficient but may still have declining glutathione levels

Another critical knowledge gap lies in the integration of GSH metabolism with metal handling and mitochondrial function

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When a person has a high intake of methionine, it may lead to an increase of homocysteine