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Neurochemical and enzymatic studies have proposed that the glutamatergic excitotoxic activity induced by pilocarpine contributes to the production of reactive oxygen species or reactive nitrogen species, overriding the neutralizing capacity of neuronal glutathione [55] , with resulting in neuronal cells loss related to the resulting oxidative and nitrosative stresses

10.1161/01.STR.0000138022.86509.2d 291 ShinD

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