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Glutathione injections are used clinically to support antioxidant capacity, particularly when oral absorption may be limited, and off label to help improve liver function

doi: 10.3389/fncel.2025.1669272 Received 19 July 2025 Revised 10 December 2025 Accepted 12 December 2025 Published 17 February 2026 Volume 19 - 2025 Edited by Luca Raiteri, University of Genoa, Italy Reviewed by Cataldo Arcuri, University of Perugia, Italy Updates Copyright 2026 Uemura, Hiro, Attachaipanich, Du, Yusof, Kinoshita, Hikosaka and Ohtsuki

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors