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During the pathogenesis of COPD, increased phosphorylation of MLKL, which partially results from PINK1-mediated mitophagy induced by cigarette smoke exposure (CSE), promotes pulmonary epithelial cell necroptosis [6] (Fig

Outdoor exposure is far less likely to produce detectable THC levels Wash hands and change clothing after exposure to heavy smoke environments THC can adsorb to skin and clothing as particles If you are tested after significant exposure , disclose the circumstances immediately to the MRO reviewing your result even though it will not reverse a confirmed positive, full transparency is always the right approach and you retain the right to a split-specimen retest within 72 hours of notification

TY developed the concept, designed and critically revised the manuscript