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35 In the brain, nicotine leads to habitual use through the nicotine receptor, and in the kidney, nicotine induces oxidative stress because nicotine is excreted by glomerular filtration and tubular secretion

Furthermore, EPS was also associated with COPD incidence, and individuals with in utero tobacco exposure, smoking during childhood/adolescence, and living in heavily polluted environments generally had a higher risk of COPD

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Harm Reduct J 8:11 Hoenicke K, Gatermann R (2005) Studies on the stability of acrylamide in food during storage