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The NOX4-dependent protective effects are also supported by a study showing exacerbated damage by methyl vinyl ketone and acrolein, both major toxic constituents of tobacco smoke extract, in cells with impaired NOX4 signalling [80]

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One study found that glycerol injected into the testes of rats (50200 L and 862 mg/kg body weight) and monkeys (119 mg/kg body weight) suppressed spermatogenesis (CIR, 2015