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Sibaud V (2018) Dermatologic ractions to immune checkpoint inhibitors: skin toxicities and immunotherapy Am J Clin Dermatol 19 (3) 345361 26

The article says this dual activation reduces hunger signals, slows gastric emptying and improves insulin sensitivity through two appetite and metabolic pathways at once

depression, anxiety, mood swings, bouts of anger, memory loss, inability to concentrate, learning disabilities, sleep deprivation, increased risk for heart attacks, strokes, high blood pressure, diabetes, loss of libido, menstrual irregularities, pre-mature menopause, obesity, loss of lean body mass, muscular weakness, and a number of other medical conditions can all arise subsequent to head trauma