These microbial shifts trigger cascading gutbrain disruption by impairing neurotransmitter signaling, suppressing SCFA production, weakening epithelial barrier integrity, and activating neuroimmune pathways, ultimately resulting in anxiety- and depression-like behaviors in rodent models (Tejkalov et al., 2023
The medication has been available since 2012 and is FDA-approved for adults with a body mass index of 30 or higher, or 27 or higher with at least one weight-related health condition
Huang CS, Chang LS, Anderson ME, Meister A: Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase
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