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At the postsynaptic sites the activation of the nAChRs also stimulates cell signaling pathways promoting the expression of synaptic proteins mediating, at cellular level, higher cognitive functions such as attention, learning and memory and other cognitive functions (McKay et al., In addition, modulators of the nAChRs such as nicotine, can have beneficial effects by stimulating cholinergic anti-inflammatory pathways (Gahring and Rogers, via the peripheral release of ACh that in turn activates the cholinergic receptors in the brain

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