Data gaps : Many peptides used in wellness clinics have stronger animal or smallscale human data than large, longterm randomized trials in healthy adults
Gene 548:294298 Mescka CP, Guerreiro G, Hammerschmidt T, Faverzani J, Coelho D de M, Mandredini V, Wayhs CAY, Wajner M, Dutra-Filho CS, Vargas CR (2015a) L-Carnitine supplementation decreases DNA damage in treated MSUD patients
The mechanistic rationale for combining the two is straightforward
To date, it has been observed that the treatment with this kind of antitumor agents causes ROS generation, mitochondrial dysfunction (including frataxin deficiency, mitochondrial DNA damage and defective components of ETC), loss in antioxidant enzymes, ion channels disturbances and nerve tissue damage (protein carbonylation and lipid peroxidation) (Areti et al., 2013) have described in vitro and in vivo biochemical effects after exposure to high concentrations of oxaliplatin, including neuronal activation of the purinoreceptor subtype 7, ROS and NO production, lipid peroxidation, loss of mitochondrial transmembrane potential and further apoptosis via caspase 3 activation
