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Psychological-related PASC (post-traumatic stress disorder, anxiety, depression, insomnia)

Discussion In the current study, SUN treatment protocol used to develop cardiotoxicity is confirmed by increasing heart weight, cardiac index and cardiotoxicity enzymatic indices, LDH and CK-MB, as well as severe histopathological changes which are manifested as scattered chronic inflammatory cells with focal fragmentation of myocardial fibers and loss of nuclei

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IAV infection can induce MAPK phosphatase-5 expression, which has been shown to inhibit IRF3 activation and type I IFN response, thereby enhancing viral replication 77