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Characterizing the Compound and Its 3-Adrenergic Link (2001) A 2001 study by Heffernan and colleagues in Endocrinology examined AOD9604 and the native fragment in obese mice alongside 3-adrenergic receptor knock-out animals, reporting evidence that 3-AR-dependent pathways contribute to the lipolytic activity observed over chronic treatment [5]

In addition, a level of evidence was assigned to each study using the Australian National Health and Medical Research Council criteria (Table 2) [56]