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The second stage consists of pathophysiological events caused by blood components and their metabolites, including BBB destruction, neural excitatory events, ion disturbances, oxidative stress, neuroinflammation, cell death, etc (Magid-Bernstein et al., 2022)

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Circulation Cardiovascular genetics

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Active -tocopherol can be regenerated by interaction with vitamin C following scavenge of a peroxy free radical

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The prolonged duration of action arises from a fatty-acid side chain that binds to albumin, delaying enzymatic breakdown

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