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persistent skin wounds, aggravation of acid-induced skin lesions and formation of keratitis-like lesions in the cornea), acquired cold and heat urticaria, psoriasis, bullous pemphigoid, eczema, photodermatoses, upper and lower airway disorders, specific and non-specific hyperreactivity, vasomotor rhinitis, asthma, chronic arthritis, and gastrointestinal lesions

Retrieved from Maia-Landim, A., Ramrez, J

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Self-reported community protocols commonly describe once-daily dosing with on/off cycling, motivated partly by the absence of any long-term human safety data and partly by a community perception of diminishing returns or tolerance over continued use