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Its safety profile has specifically been demonstrated in pediatric populations, where it has been FDA-approved and used without significant adverse outcomes [12, 13]

Administration of spironolactone, a selective MR antagonist, counteracted stress-induced mGlu2 suppression and the related development of depressive-like behavior, implicating rapid action of glucocorticoids via a receptor that is known to modulate glutamate release [20]

Patients showed a 21.9% reduction in fat mass after 48 weeks of therapy while increasing lean muscle mass by 4.5%

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