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n = 1,810,258 participants included in analysis) [ Another meta-analysis of 15 studies that addressed the risk for ASD in offspring exposed to maternal prenatal found that there was no evidence for an association (OR 1.02, 95% CI 0.931.12 for pooled analysis of all studies) [ 2 = 0.2) while higher quality studies tended to report null findings and had lower between-study variance ( 2 = 0.01) [ In a recent meta-analysis published in Nature by Jung et al., the researchers utilized a novel approach of investigating population-level smoking metrics as a moderator between maternal smoking and ASD in offspring [ p 1/2 pack of cigarettes per day was associated with a relative risk of 5.50 (95% CI: 1.9614.40)

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Nicotine primarily affects the peripheral and central nervous systems