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LA also shares structural similarities to the Vibrio cholerae zonula occludens toxin (Zot), which is an enterotoxin that disrupts intercellular tight junction structure through actin polymerization and cytoskeletal modifications that result in increased intestinal permeability through intracellular signaling (8)

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Hyponatremia and hypernatremia (sodium imbalance) Sodium abnormalities typically only occur when significant vomiting, diarrhea, dehydration, or excessive water intake accompany GLP-1 RA use

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