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Human plasma samples were analyzed using both NMR spectroscopy and LCMS/MS for -HB and AcAc quantification, while acetone was measured by GCMS

These microbial alterations of metabolic liver disease were associated with increased concentrations of molecules like 2-butanone and 4-methyl-2-pentanone that are responsible of toxic effect in hepatocytes [48]

Another study employed exposureresponse modelling of data from the SUSTAIN trial programme to estimate the impact of switching from liraglutide, dulaglutide or exenatide extended-release to semaglutide

In addition, an antifungal peptide, Histatin5, can also penetrate the membrane along the potential into the cell, act on the mitochondria, cause ATP efflux without cell lysis, inhibit mitochondrial respiration and destroy the integrity of mitochondrial membrane, and finally cause the death of Candida albicans [100]